Deep Brain Stimulation

"Kendall Lee and colleagues have curated an approachable and comprehensive overview of deep brain stimulation (DBS), with topics ranging from the biophysics of neural stimulation to applications of DBS for both established and emerging clinical indications, including memory dysfunction. Also notable are discussions of active research, such as closed loop stimulation and in vivo neurochemical monitoring. This text provides an invaluable companion for clinicians, neuroscientists, engineers, and others with an interest in the current practice and frontiers of DBS."
—Dr. Emad Eskandar, Massachusetts General Hospital, Harvard Medical School, USA

"The field of therapeutic deep brain stimulation is undergoing explosive growth, fueled by its early success in movement disorders and promise for many other common and debilitating brain disorders. Yet the mechanisms underlying its effects remain mysterious. This book covers diverse topics of relevance for current practitioners as well as newcomers to the field, including theoretical and mechanistic aspects, results of important clinical trials, and potential new brain targets and new indications."
—Dr. Philip A. Starr, University of California, San Francisco, USA

"This book is an important reference to the field of stereotactic and functional neurosurgery and covers the most important aspects of clinical practice and research in deep brain stimulation. It will be of great interest to those who are new to this field as well as experienced clinicians and investigators. Among many important topics, the book covers biophysical fundamentals of electrical stimulation, anatomy and physiology of neural networks relevant to movement disorders, chronic pain and behavioral disorders, ethical considerations, current indications of deep brain stimulation, and many areas of active clinical investigation."
—Dr. André Machado, Cleveland Clinic, USA

"This book provides a comprehensive, up-to-date description of deep brain stimulation, including its history, scientific basis, and clinical application across a vast array of neurological disorders. Although the authors are primarily from a single institution, they have done a terrific job of summarizing the state of the art, including the victories, the disappointments, and the opportunities where breakthroughs are likely next to occur. This book has tremendous value for the novice and experienced practitioner alike."
—Dr. Jonathan Miller, University Hospitals, USA