Drug Transporters in Drug Disposition, Effects and Toxicity

This comprehensive resource explores the significant role of drug transporters in drug efficacy, toxicity, and interactions, making it essential for students and professionals alike.

This book offers a detailed exploration of the critical role drug transporters play in drug disposition, efficacy, and toxicity. Drug Transporters in Drug Disposition, Effects and Toxicity delves into the complexities of drug-drug interactions and highlights recent advancements in the field. Understanding these transporters is essential, as they are key determinants of how drugs are absorbed, distributed, and eliminated in the body.

The book categorizes transporters into two main families: solute carrier (SLC) and ATP-binding cassette (ABC). These transporters are strategically located along cell membranes, facilitating the uptake of drugs into cells and their subsequent export. Their functionality is vital for maintaining cellular homeostasis, and mutations in transporter genes can lead to serious genetic disorders, including cystic fibrosis and various neurological conditions. On the flip side, certain diseases can also impact transporter function, potentially worsening the disease process.

Additionally, Drug Transporters in Drug Disposition, Effects and Toxicity addresses the challenge of multidrug resistance (MDR), which is often linked to the overexpression of specific ABC transporters. The book outlines various strategies to combat MDR, such as using ABC transporter inhibitors and employing epigenetic techniques to adjust transporter expression and function. This comprehensive resource serves as a valuable guide for graduate students and professionals eager to enhance their understanding of this dynamic and evolving field.