Lead Generation, 2 Volume Set

Methods and Strategies

Raimund Mannhold editor Hugo Kubinyi editor Gerd Folkers editor Jörg Holenz editor

Format:Hardback

Publisher:Wiley-VCH Verlag GmbH

Published:4th May '16

Currently unavailable, and unfortunately no date known when it will be back

Lead Generation, 2 Volume Set cover

In this comprehensive two-volume resource on the topic senior lead generation medicinal chemists present a coherent view of the current methods and strategies in industrial and academic lead generation. This is the first book to combine both standard and innovative approaches in comparable breadth and depth, including several recent successful lead generation case studies published here for the first time.
Beginning with a general discussion of the underlying principles and strategies, individual lead generation approaches are described in detail, highlighting their strengths and weaknesses, along with all relevant bordering disciplines like e.g. target identification and validation, predictive methods, molecular recognition or lead quality matrices. Novel lead generation approaches for challenging targets like DNA-encoded library screening or chemical biology approaches are treated here side by side with established methods as high throughput and affinity screening, knowledge- or fragment-based lead generation, and collaborative approaches. Within the entire book, a very strong focus is given to highlight the application of the presented methods, so that the reader will be able to learn from real life examples. The final part of the book presents several lead generation case studies taken from different therapeutic fields, including diabetes, cardiovascular and respiratory diseases, neuroscience, infection and tropical diseases.
The result is a prime knowledge resource for medicinal chemists and for every scientist involved in lead generation.

"it is certainly the most comprehensive and up-to-date resource currently available on the topic"......."is an excellent resource for any scientist working in lead generation"......."This is a tribute to rational
drug discovery, which combined with very thorough up-to-date literature references and emphasis on emerging technologies, makes it a book we would readily suggest taking a look at" (Dr. Robert Webster, Dr. Nuria Ortega Hernandez Bayer Pharma AG, ChemMedChem, July 2017)

ISBN: 9783527333295

Dimensions: 246mm x 178mm x 51mm

Weight: 2050g

824 pages