Asbestos and Mesothelioma

This volume offers a multidisciplinary exploration of asbestos and its link to cancer, focusing on mesothelioma. It covers epidemiology, genetic factors, treatment approaches, and recent research advancements in the field.

Asbestos and Mesothelioma offers a comprehensive exploration of the complex relationship between asbestos exposure and the development of mesothelioma. This volume brings together a multidisciplinary approach, highlighting the interplay of various factors that contribute to asbestos-related diseases. The book includes chapters that delve into the different types of asbestos and other mineral fibers, providing a historical context and discussing the epidemiology of these diseases, as well as future directions for research and prevention.

In addition to its historical and epidemiological insights, the book presents new findings on the role of asbestos-related inflammation and genetic predispositions, particularly focusing on inherited mutations of the BAP1 gene. Recent research on gene signatures, cell signaling pathways, and epigenetic mechanisms is also discussed, shedding light on the biological processes underlying mesothelioma. This information is crucial for understanding the disease's causation and progression.

The volume further updates readers on novel disease biomarkers and prevention strategies, incorporating mechanistic lessons learned from genetically engineered mouse models and three-dimensional models of mesothelioma tumorigenesis and therapeutic resistance. It also reviews current surgical techniques and advancements in molecularly targeted chemotherapy and immunotherapy for treating mesothelioma. Additionally, the book addresses legal issues surrounding asbestos exposure, making it a valuable resource for researchers, clinicians, and legal professionals alike.