Drug Discovery for Psychiatric Disorders

This comprehensive book explores advancements and future directions in drug discovery for psychiatric disorders, addressing the ongoing need for more effective treatments for conditions like schizophrenia and depression.

Drug Discovery for Psychiatric Disorders offers a comprehensive exploration of the current advancements and future trajectories in the development of medications for significant psychiatric conditions. The discovery of effective treatments for disorders such as schizophrenia and depression is recognized as a major medical achievement over the past century. These treatments have not only transformed our understanding of the underlying pathophysiology of these disorders but have also influenced the management of psychiatric patients and societal perceptions of mental health issues. Nonetheless, there remains a pressing need for more effective, safe, and tolerable therapies.

The book highlights the limitations of existing treatments, particularly for schizophrenia, which primarily target positive symptoms while often overlooking negative symptoms and cognitive dysfunction that contribute significantly to patient morbidity. Additionally, even with advancements in antidepressant therapies, a substantial portion of patients—up to 40%—remain resistant to treatment. Furthermore, the delayed onset of action for many current antidepressants can be a significant drawback for individuals seeking immediate relief from their symptoms.

This volume serves as an essential resource for researchers, practitioners, and anyone interested in the evolving landscape of psychiatric drug discovery. The editors leverage their extensive experience and connections with leading experts in the field to compile a thorough reference. The book addresses the historical context, key developments, ongoing challenges, and potential future directions in medicinal chemistry for psychiatric disorders, making it a valuable addition to the literature on this critical area of healthcare.