Essentials of Biophysics

Biophysics is that branch of knowledge that applies the principles of physics and chemistry and the methods of mathematical analysis and computer modeling to understand how biological systems work. Biophysics is a bridge between biology and physics. Biology studies life in its variety and complexity. It describes how organisms go about getting food, communicating, sensing the environment, and reproducing. On the other hand, physics looks for mathematical laws of nature and makes detailed predictions about the forces that drive idealized systems. Spanning the distance between the complexity of life and the simplicity of physical laws is the challenge of biophysics. Looking for the patterns in life and analyzing them with math and physics is a powerful way to gain insights. Biophysics can trace its roots back to the ancient Greeks and Romans, who first developed hypotheses about the physical basis for consciousness and perception. It underwent rapid development after World War II, stimulated in part by the application of nuclear physics to biological systems, including the investigation of radiation effects on living matter. In the course of these studies, physicists were introduced to biologists and biological problems, and biophysics evolved as a new scientific field. An important area of biophysical study is the detailed analysis of the structure of molecules in living systems. The best-known achievement related to this area is the model of deoxyribonucleic acid (DNA), the hereditary material of life. Biophysics is a wellspring of innovation for our high-tech economy. The applications of biophysics depend on society’s needs. In the 20th century, great progress was made in treating disease. Biophysics helped create powerful vaccines against infectious diseases. It described and controlled diseases of metabolism, such as diabetes. And biophysics provided both the tools and the understanding for treating the diseases of growth known as cancers. Today we are learning more about the biology of health and society is deeply concerned about the health of our planet. Biophysical methods are increasingly used to serve everyday needs, from forensic science to bioremediation. Biophysics gives us medical imaging technologies including MRI, CAT scans, PET scans, and sonograms for diagnosing diseases. It provides the life-saving treatment methods of kidney dialysis, radiation therapy, cardiac defibrillators, and pacemakers. Biophysicists invented instruments for detecting, purifying, imaging, and manipulating chemicals and...