Approaches to the Conformational Analysis of Biopharmaceuticals

Roger L Lundblad author

Format:Paperback

Publisher:Taylor & Francis Ltd

Published:31st May '17

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Approaches to the Conformational Analysis of Biopharmaceuticals cover

The activity of many biopharmaceutical polymers is dependent on conformation, and the next several years will see increased interest in the conformational analysis of these polymers resulting from the development of biosimilar or "follow-on" biological products. While a wide variety of approaches to analysis exists, finding the most viable ones would be much easier with a consolidated reference that details the benefits and cost of each approach, with an emphasis on real results and real products.

Explores the Growing Role of Conformational Analysis in Comparing Generic Biopharmaceuticals

Approaches to the Conformational Analysis of Biopharmaceuticals gathers the most useful techniques and methods into a single volume, putting the greatest emphasis on those approaches that have proven the most fruitful. Rather than cover specific uses of techniques in detail, this book provides commercial biotechnologists and researchers with the information and references they need to make good choices about the technology they choose to use. With a large number of references that direct readers to primary source material, it includes studies drawn from the gamut of current literature, covering physical methods, such as differential scanning calorimetry, light scanning, and analytical ultracentrifugation. It also addresses chemical methods, such as hydrogen–deuterium exchange and trace labeling, along with infrared, ultraviolet, and Raman spectroscopy.

Written by Roger Lundblad, a true pioneer in protein science, this volume supplies the necessary information researchers need to access when deciding on the most cost-effective approach, including:

  • Comparability of biopharmaceuticals
  • Characterization of follow-on biologics
  • Quality attributes of protein biopharmaceuticals
  • Confrontational analysis of biopharmaceutical products

With a clear focus on relevant commercial biotechnology, this book belongs on the shelves of those serious researchers who are paving the way for the next generation of biopharmaceutical polymers.

"Lundblad (pathology, U. of North Carolina at Chapel Hill) provides coverage of the range of technology used for the conformational analysis of biopharmaceutical polymers, intending to provide sufficient information and extensive references to establish the basis for the selection of a specific experimental approach that would be most cost-effective in the study of biopolymer conformation. Technologies addressed include native electrophoresis, affinity chromatography, size-exclusion chromatography, analytical ultracentrifugation, differential scanning calorimetry, light scattering, luminescence, near-infrared spectroscopy, mid-infrared and Fourier transform infrared spectroscopy, Raman spectroscopy, UV-VIS spectroscopy, optical rotatory dispersion and circular dichroism, nuclear magnetic resonance, chemical probes, hydrogen exchange, chemical modification,. immunology, and limited proteolysis"
2010 Book News Inc., Portland, Oregon

"Without any hesitation, I recommend this book to any researcher involved in the analysis of conformation and stability of biotechnology products (not necessarily limited to biopharmaceuticals)."
—Igor A Kaltashov. Future Science

ISBN: 9781138114944

Dimensions: unknown

Weight: 453g

368 pages