Metal-Based Neurodegeneration

From Molecular Mechanisms to Therapeutic Strategies

Roberta Ward author Robert Crichton author

Format:Hardback

Publisher:John Wiley & Sons Inc

Published:8th Nov '13

Currently unavailable, and unfortunately no date known when it will be back

Metal-Based Neurodegeneration cover

Neurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric disturbances. Many of the key factors leading to neurodegenerative diseases are similar, including the dysfunction of metal ion homeostasis, redox-active metal ions generating oxidative stress, and intracellular inclusion bodies.

Metal-based Neurodegeneration presents a detailed survey of the molecular origins of neurodegenerative diseases. Each chapter is dedicated to a specific disease, presenting the latest scientific findings,  including details of their biochemical actors (proteins or peptides), their normal and pathological conformations, and a description of the diseases characteristics, with an emphasis on the role of metal-induced oxidative stress, which can result in the production of intracellular aggregates of target proteins and peptides. 

Topics covered include:

  • Brain function, physiology and the blood-brain barrier
  • Immune system and neuroinflammation
  • Aging and mild cognitive impairment, MCI
  • Parkinson’s Disease
  • Alzheimer’s Disease
  • Creutzfelt-Jakob and related prion diseases
  • Alcoholic Brain Damage
  • Therapeutic strategies to combat the onset and progression of neurological diseases

This extensively updated, full colour, second edition of Metal-based Neurodegeneration is an essential text for research scientists and clinicians working in gerontology, neuropathology, neurochemistry, and metalloprotein mechanisms.

ISBN: 9781119977148

Dimensions: 254mm x 180mm x 26mm

Weight: 1007g

438 pages

2nd edition