Oral Bioavailability Assessment

This book offers insights into oral bioavailability, a key challenge in drug development, helping professionals enhance their understanding and practices.

Designed specifically for professionals in the pharmaceutical and biotechnology sectors, Oral Bioavailability Assessment delves into the fundamental concepts and obstacles associated with oral bioavailability. This aspect is crucial, as it represents one of the most significant challenges faced during drug discovery and development. The book provides a comprehensive overview of the factors influencing how well a drug is absorbed and utilized in the body, which is essential for effective treatment outcomes.

In Oral Bioavailability Assessment, readers will find detailed discussions on methodologies for evaluating pharmacokinetics, including the roles of drug efflux and uptake transporters in affecting oral bioavailability. By understanding these mechanisms, professionals can better navigate the complexities of drug development and work towards reducing the failure rates of drug candidates as they progress from laboratory research to clinical applications. This resource aims to bridge the gap between theoretical knowledge and practical application, enhancing the chances of success in drug development.

The book also explores the use of preclinical animal models and in vitro tools, emphasizing their relevance in translating findings to human applications. With chapters dedicated to pharmacokinetic modeling and established classification systems such as the Biopharmaceutics Drug Disposition Classification System (BDDCS) and the Extended Clearance Classification System (ECCS), Oral Bioavailability Assessment serves as a valuable guide for integrating effective strategies into medicinal chemistry practices for drug discovery and development.