Continuous Biopharmaceutical Processes

Provides a coherent and critical view on the potential benefits of various continuous processes in the biopharmaceutical industry.

Providing a balance between theoretical modelling and concrete examples, this book covers several topics involved in the continuous production of proteins for biopharmaceutical applications, focusing on multi-column counter-current chromatography, bioconjugation and protein aggregation.This innovative reference provides a coherent and critical view on the potential benefits of a transition from batch to continuous processes in the biopharmaceutical industry, with the main focus on chromatography. It also covers the key topics of protein stability and protein conjugation, addressing the chemical reaction and purification aspects together with their integration. This book offers a fine balance between theoretical modelling and illustrative case studies, between fundamental concepts and applied examples from the academic and industrial literature. Scientists interested in the design of biopharmaceutical processes will find useful practical methodologies, in particular for single-column and multi-column chromatographic processes.