Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases

Richard K Burt editor John A Snowden editor Dominique Farge editor Milton A Ruiz editor Riccardo Saccardi editor

Format:Hardback

Publisher:Taylor & Francis Ltd

Published:12th Apr '24

Currently unavailable, and unfortunately no date known when it will be back

Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases cover

This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn’s disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications.

Key Features

  • Outlines therapies and techniques for HSCT for autoimmune diseases
  • Discusses the advantages of HSCT over conventional therapies
  • Reviews the entire process of stem cell therapy from harvest and ethics to indications, efficacy, and regulatory oversight
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"Over the past 25 years, the utilization of hematopoietic stem cell transplantation (HSCT) specifically for the treatment of autoimmune diseases has gradually evolved from an initial state of ‘salvage therapy’ for severely affected patients towards a ‘standard procedure’ for selected patients in the major indications multiple sclerosis (MS) and systemic sclerosis (SSc). The recently published book entitled ‘Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases’ now summarizes all recent developments and achievements in the area and provides the evidence and state-of-the-art of HSCT and emerging cellular therapies. The selected topics comprehensively highlight all relevant aspects of the procedures. The book was developed under the direction of Richard Burt from the Northwestern University, Chicago, one of pioneers and most eminent leaders in the field, in collaboration with the co-editors Dominique Farge, Milton A Ruiz, Riccardo Saccardi and John A Snowden. The book will attract a broad readership, particularly clinical scientists, clinicians and fellows dedicated to HSCT, both from a hematologic or autoimmune disease perspective.

Overall, this book summarizes all relevant milestones in the field, extensively covering HSCT and cellular therapies in ADs, a field characterized by ongoing progress. It reflects on the dramatic developments and achievements of cellular therapies in recent years, along the dynamics of modern biologic and targeted therapies for ADs. The book is a valuable reading, serving as an ideal manual of good practices for hematologists, disease specialists, as well as researchers and young physicians. Finally, the book acknowledges the contributions and efforts of individual experts and personalities, first and foremost Richard Burt, all the co-editors and the authors of the book, to whom we bow for this work."

- Tobias Alexander and Raffaella Greco and on behalf of the European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP)

- Tobias Alexander, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin, Germany.

- Raffaella Greco, Unit of Hematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

"This is a comprehensive collection of current knowledge on hematopoietic stem cell transplantation therapy for immune diseases. With 140 international experts in the field, this book serves as a valuable resource for those who
practice and research in the field of transplantation and those who use such knowledge to care for their patients."

- Massoud Mahmoudi, DO, PhD, University of California San Francisco

ISBN: 9781032827940

Dimensions: unknown

Weight: 1430g

666 pages