Pediatric Pathology of Hematopoietic and Histiocytic Disorders

A practical guide to pediatric hematolymphoid and histiocytic diseases, describing conditions and age-related differential diagnoses.

A practical guide to hematolymphoid and histiocytic diseases in pediatric patients, covering pathological and genetic features, diagnosis and treatment of a range of conditions and newly recognised entities. Highly illustrated with annotated colour images, this book is for busy clinicians and trainees in pediatric pathology and hematology/oncology.The presentation of hematolymphoid and histiocytic diseases can vary widely between children and adults as can age-related differential diagnoses and the consequences of treatment. Providing up to date information and classification for diseases across the hematopoietic, lymphoid and histiocytic systems, the book also covers morphologic, immunophenotypic, cytogenetic, and molecular genetic features of routine and diagnostically challenging disorders in pediatric patients. Over 200 high-quality colour illustrations aid accurate diagnosis and correct interpretations when evaluating peripheral blood, bone marrow, lymph nodes and other tissues specimens. This comprehensive yet practical guide also discusses useful ancillary tests and introduces newly recognised entities identified in the current literature, such as GATA-2 haploinsufficiency, B-ALL with DUX4-IGH and ERG deletion, and ALK-positive histiocytosis. An online version of the book with expandable figures can be accessed on Cambridge Core, via the code printed on the inside of the cover.