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Protein Crystallography

A Concise Guide

Eaton E Lattman author Patrick J Loll author

Format:Paperback

Publisher:Johns Hopkins University Press

Published:13th May '08

Currently unavailable, and unfortunately no date known when it will be back

Protein Crystallography cover

The proteome remains a mysterious realm. Researchers have determined the structures of only a small fraction of the proteins encoded by the human genome. Crystallography continues to be the primary method used to determine the structures of the remaining unknown proteins. This imaging technique uses the diffraction of X-rays to determine a protein's three-dimensional molecular structure. Drawing on years of research and teaching experience, Eaton E. Lattman and Patrick J. Loll use clear examples and abundant illustrations to provide a concise and accessible primer on protein crystallography. Discussing the basics of diffraction, the behavior of two- and three-dimensional crystals, phase determination (including MIR and MAD phasing and molecular replacement), the Patterson function, and refinement, Lattman and Loll provide a complete overview of this important technique, illuminated by physical insights. The crisp writing style and simple illustrations will provide beginner crystallographers with a guide to the process of unraveling protein structure.

A useful source. Recommended. Choice 2008 It is gratifying to see such a nice piece of work and the book is highly recommended. -- Eddie Snell Reflexions: Newsletter of the American Crystallographic Association 2008 One of the main assets of the book is its many illustrations. Without exception the figures are straightforward to interpret, and the visual support enables the newcomers to the field to follow the presented material easily. -- Linda Schuldt and Manfred S. Weiss Crystallography Reviews 2009

ISBN: 9780801888083

Dimensions: 229mm x 152mm x 10mm

Weight: 227g

152 pages