The Biology of Extracellular Molecular Chaperones

This book offers a comprehensive overview of molecular chaperones, their role in the cell stress response, and their implications for various diseases.

The Biology of Extracellular Molecular Chaperones delves into the intricate mechanisms of the heat shock response, first observed in the polytene chromosomes of Drosophila. This response is crucial for cellular survival under various stresses, as it facilitates the production of novel proteins when cells are under duress. Unfolded proteins within the cell serve as a primary signal for this response, highlighting the importance of molecular chaperones in maintaining cellular integrity and function.

The book explores the evolution of the molecular chaperone concept, emphasizing its role beyond mere stress responses. It discusses how these proteins have been recognized as essential for correct protein folding and their dual nature as immunogens in microbial infections. Notably, the administration of chaperones like Hsp60 and Hsp70 has shown promise in inhibiting autoimmune diseases and cancer, revealing their therapeutic potential.

Recent findings suggest that some molecular chaperones are secreted and play significant roles in immune modulation. This emerging paradigm indicates that these proteins can influence inflammation and regulate immune responses in conditions such as coronary heart disease and diabetes. The Biology of Extracellular Molecular Chaperones brings together leading researchers to discuss these topics, making it a valuable resource for immunologists, cell biologists, and clinical researchers focused on chronic diseases and their treatments.