ABC Transporters and Multidrug Resistance

Jacques Robert editor Ahcène Boumendjel editor Jean Boutonnat editor

Format:Hardback

Publisher:John Wiley & Sons Inc

Published:30th Jul '09

Currently unavailable, and unfortunately no date known when it will be back

ABC Transporters and Multidrug Resistance cover

A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance

ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several different types of drugs.

ABC Transporters and Multidrug Resistance offers an essential resource for pharmaceutical researchers who are working to discover drugs to counteract multidrug resistance in diseases such as cancer. In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance.

This comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance.

"The book is both interesting for both novice and experienced researches in the field." (ChemMedChem, July 2010)

ISBN: 9780470227343

Dimensions: 243mm x 161mm x 27mm

Weight: 771g

480 pages