Dopamine Transporters
Chemistry, Biology, and Pharmacology
Binghe Wang editor Mark L Trudell editor Sari Izenwasser editor
Format:Hardback
Publisher:John Wiley & Sons Inc
Published:19th Aug '08
Currently unavailable, and unfortunately no date known when it will be back
Understanding the dopamine transporter can lead to new therapies for neurological disorders
This book consolidates current information on the dopamine transporter (DAT) in relationto medicinal chemistry and synthesis, biology and pathology, and pharmacology. Because of DAT's role in diseases such as Parkinson's, schizophrenia, attention deficit hyperactivity disorder (ADHD), Tourette syndrome, and drug abuse (in particular, cocaine addiction), DAT research is an exploding field. Tremendous advances have been made toward understanding how it impacts a variety of neurological disease states and disorders.
This reference provides a broad overview of current knowledge that is detailed enough to furnish a basic understanding of the biological, chemical, and pharmacological aspects of DAT in one comprehensive reference. With contributions from eminent scientists who are experts in their particular areas, Dopamine Transporters: Chemistry, Biology, and Pharmacology:
- Reviews current studies and research in the areas of DAT function, pathological conditions, cloning, molecular structure, and electrochemical characterization
- Covers findings in the medicinal chemistry of DAT-inhibitory ligands and substrates, discussing the chemical syntheses and summarizing the various structure-activity relationships of important classes of dopamine uptake inhibitors and dopamine releasers
- Has chapters that focus on technologies for future DAT study, including imaging and in vivo and in vitro methods
"Much of what will be accomplished in the coming years will require an understanding of the issues and tools presented here. No doubt, those focused on other synaptic transporters will be jealous of this resource and should demand companion volumes." (The Quarterly Review of Biology, March 2010)
"The book is well written and the chapters are well illustrated where appropriate. It is a valuable addition to the bookshelf of anyone interested in dopaminergic neurotransmission." (Journal of Medicinal Chemistry, March 2009)
ISBN: 9780470117903
Dimensions: 239mm x 158mm x 28mm
Weight: 771g
464 pages