Fatty Acid and Lipotoxicity in Obesity and Diabetes
Jamie A Goode editor Gregory R Bock editor
Format:Hardback
Publisher:John Wiley & Sons Inc
Published:23rd Nov '07
Currently unavailable, and unfortunately no date known when it will be back
The potential lipotoxic effect of accumulation of fatty acids in non-adipose tissues is thought to be a major component in the development of insulin resistance. Chronic exposure to high concentrations of free fatty acids in the blood affects pancreatic β cell function, insulin secretion and lipid synthesis in the liver, and storage in adipose tissue. Maintaining the normal levels of fatty acids requires coordinated regulation between the liver, adipose tissue and skeletal muscle.
This book deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics include lipid metabolism and adipose tissue biology, and β cell function and insulin resistance. Chapters deal with the molecular genetics and molecular physiology of energy homeostasis.
"This book will be an excellent resource for either beginning students or more established investigators in the field. The speakers are all top-notch researchers who gave clear and informative presentations. The integrative nature of the follow-up discussions and the excellent insights provided by the chair of the meeting throughout give the book an unusual coherence and consistency that is often lacking in broad, general reviews." (Doody's, April 2008)
ISBN: 9780470057643
Dimensions: 234mm x 160mm x 15mm
Weight: 476g
222 pages