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Evaluation of Drug Candidates for Preclinical Development

Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology

Chao Han editor Binghe Wang editor Charles B Davis editor

Format:Hardback

Publisher:John Wiley & Sons Inc

Published:28th Jan '10

Currently unavailable, and unfortunately no date known when it will be back

Evaluation of Drug Candidates for Preclinical Development cover

Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation

It is believed that selecting the "right" drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADMET) plays a pivotal role in drug discovery and development.

Encompassing the three major interrelated areas in which optimization and evaluation of drug developability is most critical—pharmacokinetics and drug metabolism, pharmaceutics, and safety assessment—this unique resource encourages integrated thinking in drug discovery. The contributors to this volume:

  • Cover drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, stability, drug formulation, preclinical safety assessment, toxicology, and toxicokinetics

  • Address developability issues that challenge pharma companies, moving beyond isolated experimental results

  • Reveal connections between the key scientific areas that are critical for successful drug discovery and development

  • Inspire forward-thinking strategies and decision-making processes in preclinical evaluation to maximize the potential of drug candidates to progress through development efficiently and meet the increasing demands of the marketplace

Evaluation of Drug Candidates for Preclinical Development serves as an introductory reference for those new to the pharmaceutical industry and drug discovery in particular. It is especially well suited for scientists and management teams in small- to mid-sized pharmaceutical companies, as well as academic researchers and graduate students concerned with the practical aspects related to the evaluation of drug developability.

"This is a useful reference source for those new to, or aspiring to join the pharmaceutical industry, for academics, and for students of pharmacy and pharmaceutical sciences." (Chromatographia, 1 December 2010)

"In conclusion, the book brings the areas of ADME, toxicology and pharmaceutical science together to describe the approaches used to select safe compounds with the required pharmacokinetic and physiochemical properties for progressing into clinical development". (British Toxicology Society, Winter 2010)

ISBN: 9780470044919

Dimensions: 241mm x 160mm x 21mm

Weight: 562g

304 pages