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Decoding the Genomic Control of Immune Reactions

Jamie A Goode editor Gregory R Bock editor

Format:Hardback

Publisher:John Wiley & Sons Inc

Published:9th Mar '07

Currently unavailable, and unfortunately no date known when it will be back

Decoding the Genomic Control of Immune Reactions cover

This book explores existing and potential strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve key problems in the treatment of immunological diseases and chronic infections.  The assembled genome sequences now provide important opportunities for solving these problems, but a major bottleneck is the identification of key sequences and circuits controlling the relevant immune reactions. This will require innovative, interdisciplinary and collaborative strategies of a scale and complexity we are only now beginning to comprehend.

Specific problems addressed include the following:

  • What kinds of information are we lacking to understand how the genome sequence specifies the differentiation and response of immune system cells, and system behaviour such as immunological memory and tolerance?
  • Which genome sequences and cellular circuits cause or prevent pathological immune responses to foreign pathogens, allergens or self-tissues?
  • Which host and pathogen genome sequences and cellular circuits explain the failure of sterilizing immune responses to sophisticated human pathogens such as the agents of tuberculosis, malaria, metazoan parasites and chronic viruses?

Containing contributions from a range of leading experts in the field, this book provides an important new perspective for clinical immunologists and basic researchers alike.

"…useful to…researchers and clinicians with a particular interest in pathways of regulation." (Doody's Health Services)

ISBN: 9780470027554

Dimensions: 242mm x 162mm x 17mm

Weight: 510g

232 pages