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Endocrine Manifestations of Systemic Autoimmune Diseases

Sara Walker editor Ronald Asherson editor Luis J Jara editor

Format:Hardback

Publisher:Elsevier Science & Technology

Published:12th May '08

Currently unavailable, and unfortunately no date known when it will be back

Endocrine Manifestations of Systemic Autoimmune Diseases cover

One of the first books to evaluate the role of Steroids in autoimmune rheumatic diseases

Evaluates the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to clinical involvements and focuses on the importance of steroidal hormones in the pathogenesis and therapeutical management of the autoimmune rheumatic diseases. This book discusses the perturbations of the HPA axis as source of altered steroidal synthesis.This book is one of the first to evaluate the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements and focuses on the importance of steroidal hormones in the pathogenesis and therapeutic management of the autoimmune rheumatic diseases. In particular, the chapters analyze the mechanisms of action and the involvement of adrenal steroids (glucocorticoids) in the neuroendocrine immune system, including effects on the elderly. The perturbations of the HPA axis as a source of altered steroidal synthesis will be discussed and related to some interesting pathological conditions that commonly complicate the autoimmune rheumatic diseases such as psychosis or fibromyalgia. Concerning the role of gonadal steroids (sex hormones), several chapters will discuss clinical and epidemiological evidences of their role, as well as their effects as risk factors in autoimmune rheumatic diseases, including a section on pediatrics.

ISBN: 9780444531728

Dimensions: unknown

Weight: 1020g

340 pages