Neurotoxicity of Halogenated Organic Compounds

This comprehensive volume examines the neurotoxic effects of halogenated organic compounds, providing essential insights into their environmental and health impacts.

The book Neurotoxicity of Halogenated Organic Compounds delves into the complex interactions and effects of various halogenated organic compounds. It explores three main categories: chlorinated, brominated, and fluorinated compounds, which are both legacy and emerging contaminants. The text provides essential background information, detailing the characteristics, physicochemical properties, and environmental contamination associated with these substances, as well as their implications for human health and exposure.

Chapters within Neurotoxicity of Halogenated Organic Compounds cover a wide range of topics, including a perspective on halogenated organic compounds and the neurotoxic effects of polychlorinated biphenyls (PCBs). The book discusses the neuroendocrine effects of PCBs and delves into the mechanisms of PCB neurotoxicity, highlighting the interaction between the AHR and THR pathways. Additionally, it examines the microbiome's role in the neurotoxicity of brominated flame retardants (BFRs), providing a comprehensive overview of how these compounds affect neurological health.

Further chapters focus on the neuroendocrine effects of BFRs, particularly polybrominated diphenyl ethers (PBDEs), and the neurochemical effects of halogenated organic compounds. The book also addresses the neurotoxic effects of perfluoroalkyl substances (PFAS) in both animal models and human cohorts, discussing the underlying neurochemical mechanisms and proposing future directions and regulatory considerations for these compounds. This volume serves as a critical resource for researchers and practitioners interested in environmental health and neurotoxicology.