Regulation of Downstream Targets

This volume explores various topics, including transcriptional regulation in viral infections, gene identification in endometrial cancer, and the role of heat shock proteins in cardiovascular diseases, among others. Regulation of Downstream Targets offers valuable insights into these areas.

Regulation of Downstream Targets, Volume 134 in the Advances in Protein Chemistry and Structural Biology series, explores a range of significant topics related to gene regulation and signaling pathways. The chapters delve into transcriptional regulatory mechanisms and signaling networks involved in viral infections, highlighting the complexity of how viruses manipulate host cellular processes. Additionally, the book discusses the identification of key genes linked to the pathogenesis and prognosis of endometrial cancer through integrated bioinformatics approaches, showcasing the potential of computational methods in cancer research.

The volume also addresses the differential regulation of genes in stage IB pancreatic cancer, which is associated with an increased risk of metastasis. This section emphasizes the importance of understanding gene expression patterns in cancer progression. Furthermore, it includes a comprehensive overview of AMPK-related LKB1 downstream targets and innovative bioinformatics strategies to identify novel downstream targets for cancer detection and prevention. The role of protein phosphatases and their targets in determining signaling pathways in plants is another key focus, reflecting the cross-disciplinary nature of the research presented.

Additional sections cover various topics, such as the role of calcium decoders in regulating cellular responses, the multifunctional aspects of the Importin alpha family, and the potential of Aurora Kinase A and related molecules in cancer therapy. The emerging role of heat shock proteins in cardiovascular diseases and the analysis of signaling cascades in myeloma cells treated with pristimerin further enrich the discussion, making this volume a valuable resource for researchers in the field of protein chemistry and structural biology.