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Caring for the Individual Patient

Understanding Heterogeneous Treatment Effects

National Academy of Medicine author The Learning Health System Series author David Kent editor Mahnoor Ahmed editor Danielle Whicher editor Jessica Paulus editor

Format:Paperback

Publisher:National Academies Press

Published:2nd Sep '23

Currently unavailable, and unfortunately no date known when it will be back

Caring for the Individual Patient cover

Evidence-based medicine arose from a clear need and represents a major advance in the science of clinical decision making. Despite broad acceptance of evidence-based medicine, however, a fundamental issue remains unresolved: evidence is derived from groups of people, yet medical decisions are made by and for individuals. Despite persistent assertions from clinicians that determining the best therapy for each patient is a more complicated endeavor than just picking the best treatment on average, traditional approaches have been overly reliant on the average effects estimated from the outcomes of clinical trials.

This Special Publication is based on a workshop, held by the National Academy of Medicine, that considered patient and stakeholder perspectives on the importance of understanding heterogeneous treatment effects (HTE) and best practices for implementing clinical programs that take HTE into account. For evidence to be more applicable to individual patients, we need to combine methods for strong causal inference (first and foremost, randomization) with methods for prediction that permit inferences about which particular patients are likely to benefit and which are not. Better population-based outcomes will only be realized when we understand more completely how to treat patients as the unique individuals they are.

Table of Contents
  • Front Matter
  • Summary
  • 1 Introduction
  • 2 The Promise of Personalized Evidence-Based Medicine
  • 3 Patient Perspectives of the Significance of Understanding Heterogeneous Treatment Effects
  • 4 New Methods for the Prediction of Treatment Benefit and Model Evaluation
  • 5 Next Steps for Implementation
  • 6 A Research Agenda for Personalizing Care and Improving Treatment Outcomes
  • References
  • Appendix A: Glossary
  • Appendix B: Workshop Participants, Web Participants, and Staff
  • Appendix C: Workshop Agenda
  • <

ISBN: 9780309705189

Dimensions: unknown

Weight: unknown

120 pages