Exploring Sleep Disturbance in Central Nervous System Disorders

Chronic sleep disorders affect one in five Americans, and sleep deprivation costs significant U.S. GDP loss annually. Despite the indisputable biological importance of sleep, much remains unknown about underlying mechanisms.

The National Academies Forum on Neuroscience and Nervous System Disorders convened a public workshop in November 2022. Experts and leaders from academia, industry, government, philanthropic foundations, and disease-focused non-profit organizations gathered to review current sleep science, examine the relationships between central nervous system disorders and sleep, identify potential cross-disciplinary collaborations, and discuss opportunities to better understand and mitigate sleep disturbances commonly associated with CNS disorders. This proceedings document summarizes workshop discussions.

Table of Contents

• Front Matter
• 1 Introduction and Background
• 2 Sleep Disorders and Tools for Assessment
• 3 Underlying Mechanisms and Model Systems of Sleep
• 4 Sleep Disorders and Disruption in Central Nervous System Disorders
• 5 Therapeutic Development and Biomarkers for Sleep Disorders
• 6 Advancing Sleep and Circadian Research, Education, and Clinical Care
• Appendix A: References
• Appendix B: Agenda
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