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Advancing Progress in the Development of Combination Cancer Therapies with Immune Checkpoint Inhibitors

Proceedings of a Workshop

Board on Health Care Services author National Cancer Policy Forum author National Academies of Sciences, Engineering, and Medicine author Health and Medicine Division author Sharyl J Nass editor Erin Balogh editor

Format:Paperback

Publisher:National Academies Press

Published:5th Oct '19

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Advancing Progress in the Development of Combination Cancer Therapies with Immune Checkpoint Inhibitors cover

In recent years, significant progress has been made in the clinical development and use of various types of cancer immunotherapy, all of which rely on the immune system to fight cancer. The majority of new cancer drug applications submitted to the Food and Drug Administration (FDA) are for immunotherapies or combinations involving immunotherapies. One type of immunotherapy is an immune checkpoint inhibitor. Cells in the human body have proteins that regulate the immune system response to foreign invaders (e.g., cancer cells, microorganisms). However, cancer cells can coopt these "checkpoint" proteins and thwart the immune system's ability to recognize and attack cancer cells. To help promote an immune response to cancer, researchers have developed immune checkpoint inhibitors that enable T-cells to recognize cancer cells as foreign and to prevent deactivation of an immune system response.

To examine the challenges and opportunities to develop combination cancer therapies that include immune checkpoint inhibitors, the National Cancer Policy Forum held a workshop on July 16-17, 2018, in Washington, DC. This workshop convened stakeholders with a broad range of expertise, including cancer researchers, clinicians, patient advocates, and representatives from industry, academia, and government. This publication summarizes the presentations and discussions from the workshop.

Table of Contents
  • Front Matter
  • Proceedings of a Workshop
  • Appendix A: Statement of Task
  • Appendix B: Workshop Agenda
  • <

ISBN: 9780309490863

Dimensions: unknown

Weight: unknown

88 pages