Integrating Clinical Research into Epidemic Response
The Ebola Experience
Board on Health Sciences Policy author Board on Global Health author National Academies of Sciences, Engineering, and Medicine author Health and Medicine Division author Committee on Clinical Trials During the 2014-2015 Ebola Outbreak author Patricia A Cuff editor Michelle Mancher editor Emily R Busta editor
Format:Paperback
Publisher:National Academies Press
Published:26th Jul '17
Currently unavailable, and unfortunately no date known when it will be back
The 2014–2015 Ebola epidemic in western Africa was the longest and most deadly Ebola epidemic in history, resulting in 28,616 cases and 11,310 deaths in Guinea, Liberia, and Sierra Leone. The Ebola virus has been known since 1976, when two separate outbreaks were identified in the Democratic Republic of Congo (then Zaire) and South Sudan (then Sudan). However, because all Ebola outbreaks prior to that in West Africa in 2014–2015 were relatively isolated and of short duration, little was known about how to best manage patients to improve survival, and there were no approved therapeutics or vaccines. When the World Heath Organization declared the 2014–2015 epidemic a public health emergency of international concern in August 2014, several teams began conducting formal clinical trials in the Ebola affected countries during the outbreak.
Integrating Clinical Research into Epidemic Response: The Ebola Experience assesses the value of the clinical trials held during the 2014–2015 epidemic and makes recommendations about how the conduct of trials could be improved in the context of a future international emerging or re-emerging infectious disease events.
Table of Contents- Front Matter
- Summary
- 1 Introduction
- 2 Conducting Clinical Research During an Epidemic
- 3 Assessment of Therapeutic Trials
- 4 Assessment of Vaccine Trials
- 5 Strengthening Capacity for Response and Research
- 6 Engaging Communities in Research and Response
- 7 Facilitating International Coordination and Collaboration
- Appendix A: Study Approach and Methods
- Appendix B: Clinical Trial Designs
- Appendix C: Ethical Principles for Research with Human Subjects
- Appendix D: Biographical Sketches of Committee Members and Staff <
ISBN: 9780309457767
Dimensions: unknown
Weight: unknown
342 pages