Review of the Department of Defense Research Program on Low-Level Exposures to Chemical Warfare Agents

Research related to chemical warfare agents (CWAs) has historically focused on life threatening battlefield effects caused by high level exposures to the agents, not effects associated with exposures to low concentrations of them. In this report, low level concentrations refers to exposures that may not have any immediate observed health effects, but may produce delayed health effects months or years later. Recently, there has been increased concern about the potential health effects of exposures to CWAs at low concentrations. This report reviews the Department of Defense's (DOD) Research Plan for obtaining toxicologic and other relevant data to assess risk to military personnel. The CWAs of concern include the following nerve and vesicant agents: tabun, sarin, soman, cyclosarin, VX, and sulfur mustard. The report discusses the health effects of exposure to low levels of these agents and provides guidance to DOD on appropriate risk assessment methods for assessing toxicologic risk to military personnel from low-level exposures to CWAs. The report concludes that DOD's Research Plan is well planned and many of the proposed research tasks are likely to provide valuable information to DOD in protecting military personnel.Table of Contents

• Front Matter
• Summary
• 1 Introduction
• 2 Understanding the Problem of Low-Level Exposure to Chemical Warfare Agents
• 3 Review of the Department of Defense Master Research Plan on Low-Level Exposure to Chemical Warfare Agents
• 4 Research Issues Related to Risk Assessment of Low-Level Exposure to Chemical Warfare Agents
• References
• Abbreviations