Iodotrifluoromethane

Toxicity Review

National Research Council author Board on Environmental Studies and Toxicology author Division on Earth and Life Studies author Committee on Toxicology author Subcommittee on Iodotrifluoromethane author

Format:Paperback

Publisher:National Academies Press

Published:23rd Dec '04

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Iodotrifluoromethane cover

The U.S. military is considering using a compound called iodotrifluoromethane (CF3I) for fire suppression to replace previously-used compounds (halons) that are being phased out because they deplete the ozone layer. This report reviews available toxicological data on CF3I and evaluates the scientific basis of the U.S. Army's proposed exposure limit of 2,000 parts per million (ppm). The report recommends that CF3I be used for fire suppression in normally unoccupied spaces because of its potential to cause cardiac sensitization in test animals. The report also recommends that further genotoxicity testing be conducted (testing for changes in genetic material), and that CF3I be assessed for its potential to cause cancer. Should the Army decide to use CF3I, information should be collected and evaluated on how much of the chemical or any of its degradation products might be released and how often. Table of Contents

  • Front Matter
  • Summary
  • 1 Introduction
  • 2 Physical and Chemical Properties and Efficacy
  • 3 Health Effects: Toxicity Studies
  • 4 Cardiac Sensitization
  • 5 Physiologically Based Pharmacokinetic Modeling
  • 6 Human Exposure
  • References
  • Appendix A: Biographical Information on Subcommittee on Iodotrifluoromethane
  • Appendix B: Toxicity Review for Iodotrifluoromethane (CF3I): 2002 Update

ISBN: 9780309093071

Dimensions: unknown

Weight: unknown

112 pages