Illuminating Disease
An Introduction to Green Fluorescent Proteins
Format:Hardback
Publisher:Oxford University Press Inc
Published:5th Mar '15
Currently unavailable, and unfortunately no date known when it will be back
Since scientists began experimenting with green fluorescent proteins in the middle of the 1990s, these proteins have become one of the most important tools available to researchers in modern medicine and biology. By using them to illuminate other proteins that were previously invisible even under microscope, scientists are now able to observe facets of disease that would have otherwise gone undetected. Green fluorescent proteins are a part of over three million experiments a year, and are invaluable for tasks such as tracking HIV, breeding bird flu-resistant chickens, and confirming the existence of cancerous stem cells. In Illuminating Disease, Marc Zimmer introduces us to these revolutionary proteins, acquainting readers both with the researchers responsible for the proteins' discovery as well as their wide utility. The book details the history of genetically modified fluorescent parasites and viruses, which provide scientists with new information about the spread of diseases. Green fluorescent proteins have played crucial roles in the research of malaria, AIDS/HIV, swine and bird flu, dengue, cancer, and chagas. They allow scientists and doctors to understand these diseases better, by quite literally illuminating various microscopic pieces that otherwise would have gone unseen. The book is richly illustrated, showing the many visually striking uses of GFP. Many of these scans have won awards in biological imaging competitions. Illuminating Disease is an accessible and illustrated introduction to one of the most important developments in medical research of the last several decades.
When the Nobel Prize in chemistry was awarded for the discovery of green fluorescent protein (GFP) in 2008, the Nobel Committee called GFP a guiding star for biochemistry enabling processes that were previously invisible, such as cancer cells spreading, to be strikingly visible. Marc Zimmer, has written a glowing accountof how GFP and its red, blue, yellow and orange cousins have revolutionized bio-medical research and enabled every major disease, both cause and effect, to "light-up" in the laboratory for researchers to visualize, understand and eventually conquer them. This exciting and landmark book on the wonderful story of GFP is written with great clarity, warmth and for everyone. * Dr. Robert M. Hoffman, President, Anticancer, Inc. *
I am tempted to say that this book is to GFP what the double helix is to DNA. Zimmer's pleasant and captivating account features a whole range of scientific problems, framed with personal stories and anecdotes. Zimmer manages to tell stories across many fields of disease (cancer, heart, brain, infections) that are not usually put together into one volume and thus provides a rare unifying read across biology. The nicely illustrated book clearly is a must-read for all students of biology. * Friedrich Frischnecht, Department of Parasitology, University of Heidelberg Medical School *
For many years, GFP attracted keen attention of scientists because of its unique biochemistry and practical usefulness, and simply due to its aesthetic beauty. Dr. Zimmer describes a lot of facts of medicine and basic biology, but at the same time does not forget to explain all basics to non-scientist readers, often suggesting surprising and illustrative parallels with everyday life. The book is full of stories of people who made key discoveries and technical breakthroughs in the field, and it shows an exciting flow of appearance and implementation of scientific ideas. * Sergey Lukyanov, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry *
Illuminating Disease' achieves a difficult synthesis between discussing various diseases that are rarely mentioned within a single book and the molecular biology of fluorescent proteins without losing accessibility for a generalist reader. It is this mix that makes 'Illuminating Disease' stand out. Zimmer's account will provide students with an access point to the history and application of fluorescent proteins. There really is something for everyone here: from the interested lay-scientist through to the undergraduate student to those researchers that take GFP for granted in their daily research. And it is with this appreciation that the current book will serve the scientific community well. * Bioessays *
The book is well written, and the discussion is sufficiently detailed to be useful but not so complex as to overwhelm readers with minutiae. This is an informative read for those in the health science disciplines. Highly Recommend. * J. M. Tomich, CHOICE. *
ISBN: 9780199362813
Dimensions: 155mm x 239mm x 23mm
Weight: 635g
240 pages