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Phase I Cancer Clinical Trials

A Practical Guide

Marc Buyse editor Elizabeth A Eisenhauer editor Christopher Twelves editor

Format:Paperback

Publisher:Oxford University Press Inc

Published:7th May '15

Currently unavailable, and unfortunately no date known when it will be back

Phase I Cancer Clinical Trials cover

Phase I trials are a critical first step in the study of novel cancer therapeutic approaches. Their primary goals are to identify the recommended dose, schedule and pharmacologic behavior of new agents or new combinations of agents and to describe the adverse effects of treatment. In cancer therapeutics, such studies have particular challenges. Due to the nature of the effects of treatment, most such studies are conducted in patients with advanced malignancy, rather than in healthy volunteers. Further, the endpoints of these trials are usually measures adverse effects rather than molecular target or anti-tumor effects. These factors render the design, conduct, analysis and ethical aspects of phase I cancer trials unique. As the only comprehensive book on this topic, Phase I Cancer Clinical Trials is a useful resource for oncology trainees or specialists interested in understanding cancer drug development. New to this edition are chapters on Phase 0 Trials and Immunotherapeutics, and updated information on the process, pitfalls, and logistics of Phase I Trials

This is a well-written, well-structured book that comprehensively covers the unique aspects of phase I clinical trials in cancer patients. This may be the only book of its kind and will be appropriate for a wide audience. * Karen L. Reckamp, MD, MS; Doodys Reviews *

ISBN: 9780199359011

Dimensions: 155mm x 231mm x 23mm

Weight: 517g

368 pages

2nd Revised edition