Stimulant Drugs and ADHD
Basic and Clinical Neuroscience
Mary V Solanto editor Amy F T Arnsten editor F Xavier Castellanos editor
Format:Hardback
Publisher:Oxford University Press Inc
Currently unavailable, and unfortunately no date known when it will be back
Stimulant drugs are widely used in the treatment of ADHD in children and adults. Hundreds of studies over the past 60 years have demonstrated their effectiveness in improving attention span, increasing impulse control, and reducing hyperactivity and restlessness. Despite widespread interest in these compounds, however, their mechanisms of action in the central nervous system have remained poorly understood. Recent advances in the basic and clinical neurosciences now afford the possibility of elucidating these mechanisms. The current volume is the first to bring this expanding knowledge to bear on the central question of why and how stimulants exert their therapeutic effects. The result is a careful, comprehensive, and insightful integration of material by well-known scientists that significantly advances our understanding of stimulant effects and charts a course for future research. Part I presents a comprehensive description of the clinical features of ADHD and the clinical repsonse to stimulants. Part II details the cortical and subcortical neuroanatomy and functional neurophysiology of dopamine and norepinephrine systems with respect to the regulation of attention, arousal, activity, and impulse control on the basis of animal studies. Part III is devoted to clinical research, including recent studies of neuroimaging, genetics, pharmacodynamic and pharmacokinetic properties of stimulants, effects on cognitive functions, neurophysiological effects in humans with and without ADHD and in non-human primates, and comparison of stimulants and non-stimulants in the treatment of ADHD. Part IV is a masterful synthesis that presents alternative models of stimulant drug action and generates key hypotheses for continued research. The volume will be of keen interest to researchers and clinicians in psychiatry, psychology, and neurology, neuroscientists studying stimulants, and those persuing development of new drugs to treat ADHD.
"This book is an ambitious, even courageous, attempt to pull together evidence from the basic and clinical neurosciences that may ultimately help explain how stimulant drugs act to reduce the behavioral and cognitive symptoms associated with attention-deficit-hyperactivity disorder (ADHD)." --Contemporary Psychology "This book is an ambitious, even courageous, attempt to pull together evidence from the basic and clinical neurosciences that may ultimately help explain how stimulant drugs act to reduce the behavioral and cognitive symptoms associated with attention-deficit-hyperactivity disorder (ADHD)." --Contemporary Psychology "...a volume that will interest almost anyone who works with attention deficit hyperactivity disorder (ADHD) in either clinics or research programs"--The Journal of Nervous and Mental Disease "...a timely addition to the ever growing literature on the most controversial of pharmacotherapies for children and adolescents...most of the chapters are engaging....The clinical chapters by Mary Solanto(on the clinical features of ADHD), Laurence Greenhill(on the clinical effects of stimulant medication), and the final, challenging chapet by Solanto, Amy Arnsten, and Xavier Castellanos are outstanding."--The Lancet, 2001 "This slender volume is an excellent collection of reviews on ADHD in the context of modern psychopharmacology and neuroscience....The quality of all the chapters is consistently of a very high standard, each text a gem on its own. They are concisely written and densely packed with relevant information. The materials are accessible, despite being technical in nature...a superb set of essays....Overall, this is--and I believe will remain for some time--a benchmark publication, relevant to any clinician who prescribes ADHD psychopharmacological treatment, and to investigators in ADHD research from medical or neuroscience backgrounds alike."--Journal of Child Psychology and Psychiatry
ISBN: 9780195133714
Dimensions: 164mm x 238mm x 27mm
Weight: 680g
424 pages