Vascular Disease, Alzheimer's Disease, and Mild Cognitive Impairment
Advancing an Integrated Approach
Kenneth M Heilman editor David J Libon editor Melissa Lamar editor Rodney A Swenson editor
Format:Hardback
Publisher:Oxford University Press Inc
Published:22nd Apr '20
Currently unavailable, and unfortunately no date known when it will be back
Alzheimer's disease (AD) and vascular dementia (VaD) are commonly viewed as the first and second most common types of dementia, respectively. The traditional paradigm has been to view and treat each illness as a separate entity with a separate pathophysiology. However, clinical and pathological studies suggest that the boundary separating AD and VaD, as well as their mild cognitive impairment (MCI) analogs, is not well defined. Thus, there is increased interest in viewing these diseases along a spectrum because of the significant overlap in the characterization and diagnosis of AD, VaD, and MCI. The focus of this edited volume is to examine how AD and VaD, as well as their MCI analogs, are best viewed as a heterogeneous, intersecting, if not a continuous disease state rather than separate, distinct entities. This book examines this approach by providing empirically based evidence, reviews of the literature, and chapters by key leaders in the field and will be of interest to clinical neuropsychologists and anyone studying or treating dementia in its many forms.
A 'must-read,' very timely, comprehensive interdisciplinary overview illuminating the complexity of the dementia syndromes, particularly Vascular-Alzheimer spectrum disorders." -Sandra E. Black, Professor of Medicine (Neurology), Department of Medicine, Sunnybrook HSC and University of Toronto
This remarkable volume brings us the most current understanding on the undeniable role of vascular disease risk factors in both neurodegenerative and vascular dementias. Expert authors fittingly also focus on prodromal phases of the most common dementia types including mild cognitive impairment and vascular cognitive impairment. They highlight vascular disease that robustly influences relevant neuropsychological, neuroimaging as well as neuropathological substrates of dementia syndromes." -Raj Kalaria, Professor of Cerebrovascular Pathology (Neuropathology), Newcastle University
There is an increasing realization that the most common neuropathology underlying dementia and MCI is the combination of plaques, tangles, as well as alterations due to vascular disease. In this important book Libon, Lamar, Swenson, and Heilman have assembled an impressive set of contributors to describe the mechanisms, markers, and treatment implications of combined AD and vascular pathology commonly present in dementia and MCI. This endeavor stands to advance our knowledge and shift current research and clinical paradigms that study neurodegenerative illness." -Glenn Smith, Chair of Psychology, University of Florida
In this book, world-leaders in the area summarize current knowledge on the heterogeneity of Alzheimer's disease, vascular dementia, and mild cognitive impairment, and how these conditions are on a continuum and influence and shape the expression of each other. This book is a must for researchers, clinicians, and others interested in the heterogeneity and overlap of the most common forms of cognitive decline, and will be a standard reference for many years." -Ingmar Skoog, Professor, Institute of Neuroscience and Physiology and Director of the Centre for Ageing and Health, AgeCap, University of Gothenburg, Sweden
ISBN: 9780190634230
Dimensions: 239mm x 160mm x 36mm
Weight: 839g
504 pages